Aside from the incidence of gastric ulceration, celecoxib exhibits a similar adverse drug reaction (ADR) profile to other NSAIDs.
Gastrointestinal ADRs
In theory the COX-2 selectivity should result in a significantly lower incidence of gastrointestinal ulceration than traditional NSAIDs. The main body of evidence touted to support this theory were the preliminary (6 month) results of the Celecoxib Long-term Arthritis Safety Study (CLASS) as published in 2000, which demonstrated a significant reduction in the incidence of gastrointestinal ulceration in those taking celecoxib versus ibuprofen or diclofenac. (Silverstein et al, 2000) The final results from the
class study, however, did not indicate any advantage of celecoxib over the other NSAIDs
in the study.
Cardiovascular risk
The withdrawal of rofecoxib from the market in 2004 due to an increased risk of adverse cardiovascular events led to the suspicion that this was a class effect. Indeed an increased risk of heart attack and stroke was found in a National Cancer Institute study studying the use of 400-800 mg celecoxib daily for the prevention of colorectal adenoma (relative risk 2.3-3.4 vs
placebo).
There is still much conjecture about the adverse
effects of Celebrex and
personal injury however, as to whether this risk is significant for the majority of patients being treated with lower doses for
osteoarthritis.
Allergy
Celecoxib contains a sulfonamide moiety and may cause allergic reactions in those allergic to other sulfonamide-containing drugs. This is in addition to the contraindication in patients with severe allergies to other NSAIDs.
Adverse Effects
of Celebrex Best Sellers from
Amazon.com
• In Print Science News
To fight off an infection or illness, the body shifts into a slow down mode that mirrors some symptoms of depression. In fact, scientists now think the immune response itself may even cause the mood disorder.
• Dr. Ed Explains The Drugs Doctors Avoid KLTV 7 Tyler
Mens Health Magazine just came out with a list of the top eight drugs that they say doctors themselves are hesitant to use.
• 8 Drugs Doctors Wouldnt Take MSNBC
Plenty of M.D.s know which prescription and over the counter drugs are duds, dangers or both. So we asked them, Which medications would you skip Their list is your second opinion.
• Online Pharmacy Ordered To Pay FTC 15.8 Million Law.com Via Yahoo Finance
Saying they dispensed deception, a federal judge in Atlanta has ordered the founders and operators of a now defunct online pharmacy business to pay the U.S. Federal Trade Commission 15.8 million for fraudulent claims associated with the drugs they peddled.
• Online Pharmacy Ordered To Pay FTC 15.8 Million Law.com
Saying they dispensed deception, a federal judge in Atlanta has ordered the founders and operators of a now defunct online pharmacy business to pay the U.S. Federal Trade Commission 15.8 million for fraudulent claims associated with the drugs they peddled. In his order, U.S. District Judge Charles A. Pannell also found Dr. Terrill Mark Wright, a physician associated with the online
IMPORTANT NOTICE:
The information provided by FactsOfLaw.com does not
constitute legal advice or any other type of advice and is
provided for educational purposes only without
warranty of any kind. FactsOfLaw.com has not
reviewed the information on this page for accuracy
and is not responsible for any errors, omissions or
inaccuracies. For legal advice you should
consult a licensed attorney. Source: wikipedia.org