When drugs that have been approved by the FDA are shown to cause unexpected and dangerous conditions in patients, they can be recalled and withdrawn from the market.  Usually the risks did not surface during the Phase III clinical trials and only became apparent from wide-use patient experience.

Drugs that are now listed as dangerous drugs include:

• alosetron (2000) - withdrawn due to risk of fatal complications of constipation; reintroduced 2002 on a restricted basis
• bextra (2005) - withdrawn due to risk of cardiovascular events
• cerivastatin (2001) - withdrawn due to risk of rhabdomyolysis
• cisapride (2000s) - withdrawn in many countries due to risk of cardiac arrhythmias
• diethylstilbestrol (1970s) - withdrawn due to risk of teratogenicity
• duract (1998) - withdrawn due to risk of hepatitis
• Fen-phen - popular combination of fenfluramine and phentermine; phentermine remains on the market, dexfenfluramine & fenfluramine (1997) later withdrawn
• lysergic acid diethylamide (LSD) (1950s-1960s), marketed as a psychiatric cure-all; withdrawn after it became widely used recreationally by hippies
• methaqualone (1984) - withdrawn due to risk of addiction and overdose.
• meridia (1998) - withdrawn do to link to 19 heart attack deaths
• mibefradil (1998) - withdrawn due to dangerous interactions with other drugs
• phenformin and buformin - withdrawn due to risk of lactic acidosis
• rapacuronium (2001) - withdrawn in many countries due to risk of fatal bronchospasm
• rofecoxib (Bextra) (2004) - withdrawn due to risk of myocardial infarction
• terfenadine (1998) - withdrawn due to risk of cardiac arrhythmias; superseded by fexofenadine
• thalidomide (1950s-1960s) - withdrawn due to risk of teratogenicity; returned to market as an anti-neoplastic drug under FDA orphan drug rules
• ticrynafen (1982) - withdrawn due to risk of hepatitis
• triazolam (1991) - withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions
• troglitazone (2000) - withdrawn due to risk of hepatotoxicity; superseded by pioglitazone and rosiglitazone
   

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