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Facts - Books - News    U.S. Facts Of Law:

Treatment of Mesothelioma

Treatment of mesothelioma using conventional therapies has not proved successful and patients have a median survival time of 6 - 12 months after presentation. The clinical behavior of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity which favors local metastasis via exfoliated cells, invasion to underlying tissue and other organs within the pleural cavity, and the extremely long latency period between asbestos exposure and development of the disease.

Surgery, either by itself or used in combination with pre- and post-operative adjuvant therapies has proved disappointing with a 5 year survival rate of less than 10%. Although the tumor is highly resistant to radiotherapy and chemotherapy, these regimens are sometimes used to relieve symptoms arising from tumor metastases such as obstruction of a major blood vessel.

Treatment regimens involving immunotherapy have yielded variable results. For example, intrapleural inoculation of Bacillus Calmette-Guérin (BCG) in an attempt to boost the immune response, was found to be of no benefit to the patient. Mesothelioma cells proved susceptible to in vitro lysis by LAK cells following activation by interleukin (IL)-2, but patients undergoing this particular therapy experienced major side effects. Indeed, this trial was suspended in view of the unacceptably high levels of IL-2 toxicity and the severity of side effects such as fever and cachexia. Nonetheless, other trials involving interferon alpha have proved more encouraging with 20% of patients experiencing a greater than 50% reduction in tumor mass combined with minimal side effects.

The failure of conventional therapies in combating this aggressive tumor has initiated great interest in the development of alternative forms of therapy, especially those capable of specifically destroying diseased cells but not surrounding healthy tissue.

 

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Mesothelioma: An entry from Thomson Gale's Gale Encyclopedia of Cancer, 2nd ed.
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Treatment of Mesothelioma News

HOME PAGE The Hindu
Sensex plunges 570 pts Mumbai, July 3 Stock markets suffered another major fall on Thursday, wiping out most of yesterdays gains. Crude touching 146 a barrel coupled with poor job data in US dampened sentiment in all major markets.The BSE

Cancer Researchers Interests Coalesce In Kitchen Honolulu StarBulletin
An espresso maker sputters fragrant liquid into delicate china cups while Italian music plays from the speakers behind Dr. Michele Carbones desk in the biomedical research building of the John A. Burns School of Medicine.

Cancer Battler Backing Drugs Speedup Plan Belfast Telegraph
A battling Co Derry mother who spearheaded the campaign to bring a breast cancer wonderdrug to Northern Ireland welcomed efforts to speed up the assessment of drugs for use on the NHS.

Why Are Our Schools Full Of Deadly Asbestos And Why Isnt Anything Being Done ...
Dont tell anyone, but we have a problem. Most of the 24,000 schools in this country have significant amounts of asbestos.

International Symposium On Malignant Mesothelioma Research Newswise
Dr. Harvey Pass, professor of cardiothoracic surgery and surgery and director of the division of thoracic surgery and oncology at NYU Langone Medical Center and its NYU Cancer Institute, is the recipient of the Pioneer Award.

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