Vioxx

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Facts - Books - News    U.S. Facts Of Law:

Vioxx, COX-2 Selective Inhibitor

Rofecoxib belongs to the group of NSAIDs known as COX-2 selective inhibitors or coxibs (CycloOXygenase-2 Inhibitors). Being COX-2 selective means that these drugs act specifically on one form of the cyclooxygenase (COX) enzyme, namely the COX-2, whereas previous NSAIDs inhibited both COX-1 and COX-2. This specificity allows rofecoxib and other COX-2 inhibitors to reduce inflammation and pain while minimizing undesired gastrointestinal adverse effects - peptic ulcers - that are common with non-selective NSAIDs such as aspirin, naproxen, and ibuprofen.

Interestingly, at the time of its withdrawal, rofecoxib was the only coxib with clinical evidence of its superior gastrointestinal adverse effect profile over conventional NSAIDs. This was largely based on the VIGOR (Vioxx GI Outcomes Research) study, which compared the efficacy and adverse effect profiles of rofecoxib and naproxen. (Bombardier et al., 2000).

 

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Vioxx COX-2 Selective Ihibitor News

FDA Focus On Safety Slows Drug Approval San Diego UnionTribune
Nearly four years after Merck Co. yanked the painkiller Vioxx off the market, beleaguered pharmaceutical industry executives say they are facing a tough new regulatory climate that is altering the landscape of drug development. Over the past 16 months, Schering Plough Corp. Chief Executive Fred Hassan and his top scientists have pulled the plug on two drug development projects one for

Some 59,000 Register For Vioxx Settlement Asbury Park Press
More than 59,000 people have registered claims against Readington based drugmaker Merck Co. for injury from painkiller Vioxx, and administrators have enough records to review about 9,100 of those claims.

More Than 59,000 People Register For Vioxx Deal CourierPost
More than 59,000 people have registered claims against drugmaker Merck Co. for injury from painkiller Vioxx, and administrators have enough records to review about 9,100 of those claims.

NEW ORLEANS 59,000 Register For Vioxx Settlement The Santa Rosa Press Democrat
More than 59,000 people have registered claims against drugmaker Merck amp Co. for injury from painkiller Vioxx, and administrators have enough records to review about 9,100 of those claims.

More Than 59,000 Register For Vioxx Settlement ABC 13 Houston
More than 59,000 people hope to share in drugmaker Merck Co.s settlement of lawsuits claiming injury from the painkiller Vioxx, and administrators have enough records to review about 9,100 of those claims.

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